What minimum inpatient monitoring and discharge criteria should be required after single high-dose liposomal amphotericin B induction for HIV-associated cryptococcal meningitis when the patient has persistent intracranial hypertension requiring serial lumbar punctures?

If a patient has persistent ICH despite serial LPs, I would ask neurosurgery to place a lumbar drain. I would also continue the liposomal amphoB until the ICH came down. In addition, the CSF cell counts, glucose, and protein should be followed along with CSF CrAg/culture to confirm that all are impr...

There are Cryptococcal meningitis guidelines by IDSA with a section devoted to what Dr. @Dr. First Last mentioned (IDsociety.org). I realize that we are getting pressure to think about discharge as soon as every patient is admitted, but this particular patient will need at least two weeks of Amphote...