What neoadjuvant regimen would you give a patient with multicentric IDC consisting of TNBC and concurrent ER/PR- HER2+ breast cancer with ER/PR- HER2+ axillary LN mets?

Topics: Breast Cancer • Medical Oncology • Triple negative • Her2+ • Breast Cancer, Non-metastatic

Answer from: Medical Oncologist at Academic Institution

In cases where we had heterogenous multicentric TNBC and HER2+ disease and the patient had no major cardiac risk factors, we tended to use more AC-THP vs. TCHP in those cases. The addition of the anthracycline to the taxane was felt to be appropriate to better cover both types of cancers (although c...

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Medical Oncologist at Alvin & Lois Lapidus Cancer Institute Northwest Hospital
Agree that carboplatin/docetaxel is very active in...

Answer from: Medical Oncologist at Academic Institution

This question is harder to answer now with the use of TCHP for HER2+ disease and the use of KEYNOTE-522 regimen for TNBC (i.e. would be easier in the AC-TH era). I feel like in this case, I would start with TCHP, and if pCR, feel comfortable to omit the anthracycline for both the TNBC and the HER2+ ...

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