What neoadjuvant strategies do you utilize for initially unresectable biliary tract cancer?

Topics: Gastrointestinal Cancers • Medical Oncology • Liver and Pancreas Tumors • NCI-CCC Tumor Board Question • University of Wisconsin

In your experience, what approach has been successful to bridge to surgery?

Answer from: Medical Oncologist at Academic Institution

Great question. While there is not prospective data, I tend to use the triplet chemo regimen of gem/cis/nab-paclitaxel based on the 20% conversion rate seen in this phase 2 study. There is an ongoing neoadjuvant study in IHCC that is investigating the triplet, but this is only open at select centers...

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Medical Oncologist at Bon Secours Saint Mary's Hospital
Thank you for the discussion on the topic! For som...

Answer from: Radiation Oncologist at Academic Institution

Primary biliary adenocarcinoma (cholangicarcinoma) occurs in 5 forms. Intrahepatic, hilar, hilar and intrahepatic combined, mid bile duct, and periampullary. Periampullary (distal bile duct) should be managed by an algorithm suitable for pancreatic cancer. The other 4 presentations are less common a...

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