What patient clinical factors do you find most impact a patient's "beta-blocker window" and their ability to maintain and tolerate beta-blocker therapy?  

Hypotension (SPB<90), bradycardia (HR <50) and refractory (grade 3) ascites are typically considered triggers to at least hold but likely stop NSBB. On the other end of the window, evidence of clinically significant portal hypertension (CSPH) is the typical trigger to consider starting NSBB tr...