Multiple agents can be used to treat recurrent thymoma that requires systemic therapy. Thymoma can be indolent and may not require systemic therapy for some time. Radiation therapy can also postpone the need for systemic treatment in selective cases. Therefore, in some cases, observation is appropri...

Good question. Enrolment in clinical trials is ideal since there is really no standard of care option. As mentioned by others, single agents are modestly effective in stabilizing disease. Octreotide is a great option if the tumor is dotatate positive, but it rarely is. I tend to use TKIs such as eve...

Agree with Dr. @Dowlati that observation is frequently an appropriate approach given the slow progression and paucity of symptoms seen with most metastatic thymomas. Although pleural 'drop' metastases are by far the most common metastatic site, it is remarkable how asymptomatic most patients ar...