What therapies do you offer to patients with hypophosphatasia and low bone density who do not qualify for enzyme replacement therapy?

I have seen several patients like this. I recommend vitamin D to maintain 25-hydroxyvitamin D of 40-60 ng/mL, which usually requires 3000-5000 IUs daily. A good source of dietary calcium; my preference is 1000 mg from dairy sources, which not only provides a good source of bioavailable calcium but a...