What treatment regimen would you recommend for young adults with platinum refractory relapsed germ cell tumors?

We assess the patient risk by IPFSG score, and if it is high score or has extragonadal primary site then we consider tandem high dose chemotherapy and autologous transplantation https://onlinelibrary.wiley.com/doi/full/10.1002/acg2.47

The data sometimes is unclear on the role of HDCT .

- the larges...

At USC, we use a Gemcitabine-based regimen (Gemcitabine/Oxaliplatin/Paclitaxel) similar to what has been described by Bokemeyer et al., PMID 18006893. We designed a dose-dense form of GOT, cycled every 14 days, with paclitaxel 170 mg/m2 on day 1 (as compared to 80 mg/m2). We escalate the oxaliplatin...