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What treatment would you offer for a patient with unresectable triple negative breast CA who remains unresectable after completion of dd AC-T?

Presuming that imaging does not show distant metastatic disease, what would you offer? What about if the patient were PD-L1 negative?
4 Answers
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Medical Oncology · Warren Alpert Medical School of Brown University
Answered on

If the patient was responding to treatment but maybe presented with a large mass and had an insufficient response to chemo to convert her to resectability, further chemotherapy with carboplatin, preferably in combination with another agent - and I wouldn't rule out using docetaxel, given the activit...

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Medical Oncology · Washington University School of Medicine
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We had a trial of platinum in combination with radiation therapy in this situation to improve local response. She may be eligible for clinical trials of novel treatments.

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Medical Oncology · University of Hawai'i Cancer Center
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It depends on the clinical scenario. I am assuming that this question is based on that, with one more push of the response, the patient can be a candidate for local therapy. In this situation, I usually like to use gemcitabine and carboplatin, which provide a platinum-containing regimen. Most patien...

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Radiation Oncology · Washington University School of Medicine
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I defer to my colleagues, more knowledgeable in Medical Oncology, regarding systemic therapy options for this patient. Obviously, she is a prime candidate for breast and regional nodal irradiation. The breast dose will depend on the final tumor response and possible eligibility for a mastectomy (pre...

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