Topics:
Melanoma/Skin Cancer • Medical Oncology
What treatment would you offer to a patient after resection of a solitary metastatic melanoma from the brain without evidence of other sites of disease?
Assuming SRS to the resection cavity is advised, would you recommend early immunotherapy to improve outcomes/enhance a possible abscopal effect?
Answer from: Medical Oncologist at Community Practice
Resected stage IV melanoma, including patients with resected brain metastases, was included in the CHECKMATE 238 study of adjuvant nivolumab vs. adjuvant ipi published by Weber et al in NEJM 2017, which was a positive study overall with improved RFS in the nivolumab arm. The magnitude of effect in ...
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