My answer would differ for a primary cutaneous angiosarcoma that has spread to the GI tract vs a primary visceral angiosarcoma. Outside of a clinical trial, for a young fit patient with a primary cutaneous angiosarcoma, taxane based chemotherapy would be my preferred option, usually weekly paclitaxe...

Clearly an uncommon presentation - seen "more often" in HIV associated KS. One needs to be careful in looking out for a significant GI bleed or even a perforation as the tumors respond to chemotherapy. Starting with a less myelosuppressive regimen from the options listed to gain some control may be ...

Here is my n=1 of a long survivor of multifocal gut angiosarcoma. 50-year-old presents with GI bleed 2/2013; 2 widely spaced foci of angiosarcoma in small bowel. Resected (with two anastomoses, preserving intervening bowel!). Imaging with widespread metastatic disease. Enrolled in phase 3 study ...