What whole brain radiation dose would you recommend for primary CNS lymphoma with partial response to HD-MTX-R and R-ICE and planned for concurrent ibrutinib?

There are many uncertainties in how to optimal treat patients with PCNSL. It is clear that high-dose MTX-based regimens should be pursued when feasible. The role, if any, of RT is controversial. If pursued, a WBRT-based approach is generally considered most appropriate.

With that said, if a patient o...

I principally agree with the comments by Prof. @Dr. First Last. Just some extra thoughts:

A patient with partial response to HD-MTX-R is very unlikely to achieve durable control of the disease, if no high-dose chemotherapy with ASCT or some novel approach (CAR-T) is planned/possible.

On occasion, I...