What workup do you perform to evaluate for underlying triggers/associated conditions in a pediatric patient with autoimmune hemolytic anemia?
1 Answer
Mednet Member
Pediatric Hematology/Oncology · University of Catania
Answered on
The diagnostic workup that I would recommend in order to rule out a possible underlying condition includes the following:
- Extensive red blood cell typing in anticipation of possible transfusion. Further immune-haematological investigations: C3, C4, CH50 Auto-antibodies (ANA, anti DNA), antiphospholipid antibodies, RA test.
- Thyroid function and anti-thyroid antibodies (anti-TG, anti-TPO).
- Lymphocyte subpopulations (CD3, CD4, CD8, CD19, CD16, CD56) - Double-negative T cells: CD3+, CD4-, CD8-, TCR alpha/beta+.
- Hepatitis B and C markers and HIV serology, coagulation screen, blood test, serum total protein and protein electrophoresis Immunoglobulin class quantification, C-reactive protein
- EBV, CMV, Parvovirus B19, HSV serology
- Other assessme...
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