What would be your next line of treatment for disease control in a pediatric patient with metastatic hepatocellular carcinoma in partial response after multiple therapies?

Topics: Pediatric Oncology • Liver and Pancreas Tumors • Hepatocellular Carcinoma

The patient already received PLADO+sorafenib, Y90, and Atezolizumab/Bevacizumab complicated by recurrent episodes of bleeding from esophageal varices. Metastases have resolved and primary tumor has shown partial response to prior treatment.

Answer from: at Academic Institution

Dear Dr. @Kritika Patel, Does the patient have an underlying hepatopathy (guessing yes, given the presence of varices)? And how old is the patient? Also - what was the AFP at diagnosis and what is it now? And what is the underlying liver function like? Final question - has the tumor been seque...

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at Lurie Children’s Hospital
Thank you for your reply, Dr. @Arun Rangaswami. To...

Answer from: at Community Practice

Hello Dr. @Kritika Patel, Of course, I agree with Dr. @Arun Rangaswami about getting more information - for me, the main question is: Is this fibrolamellar carcinoma (FLC)? Adolescent and otherwise healthy and lack of underlying liver disease (and usually normal AFP) are the hallmark of FLC. We nee...

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