What would be your next line of treatment for disease control in a pediatric patient with metastatic hepatocellular carcinoma in partial response after multiple therapies?
Dear Dr. @Dr. First Last,
Does the patient have an underlying hepatopathy (guessing yes, given the presence of varices)? And how old is the patient? Also - what was the AFP at diagnosis and what is it now? And what is the underlying liver function like?
Final question - has the tumor been sequenced ...
Hello Dr. @Dr. First Last,
Of course, I agree with Dr. @Dr. First Last about getting more information - for me, the main question is: Is this fibrolamellar carcinoma (FLC)? Adolescent and otherwise healthy and lack of underlying liver disease (and usually normal AFP) are the hallmark of FLC. We need...
Gemcitabine (500 mg/m² IV) + oxaliplatin (50 mg/m² IV) every 2 weeks + lenvatinib 4 mg PO daily, or nivolumab (2 mg/kg IV) + gemcitabine (500 mg/m² IV) every 2 weeks + lenvatinib 4 mg PO daily.