What would be your recommended target volume for a high-risk head and neck cutaneous squamous cell carcinoma with microscopic (not clinical) perineural invasion and negative sentinel node biopsy?

That is a good question. Our pathologist takes perineural involvement one level further by describing the nerve involvement as either being small or large nerves. If small cutaneous nerves are involved I make certain that my margins are at least 1.5 cm beyond the clinical tumor margin. If a large ne...