What would be your second line approach for a patient with MSI-H metastatic colon cancer who progressed on first line chemotherapy?

Topics: Gastrointestinal Cancers • Medical Oncology

Would you switch chemotherapy regimens (i.e if the patient received FOLFOX/Avastin, change to FOLFIRI/Avastin)? Would you treat wuth immunotherapy per the latest data from Checkmate 142?

Answer from: Medical Oncologist at Academic Institution

I would definitely favor nivolumab + ipilimumab in this setting. Although we don't have a randomized comparison, the response rate, duration of response, and PFS reported in CheckMate 142 clearly exceed what we would expect with second-line chemotherapy. This is even more remarkable when you conside...

Comments

Medical Oncologist at Ralph Lauren Center for Cancer Care and Prevention
Very helpful. Thank you!

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