When and how should we be stopping GLP-1 Receptor Agonist/Dual Agonist therapy?

When and how do you approach GLP-1 receptor and dual agonist therapy cessation?

• I immediately stop GLP-1 receptor and dual agonist therapy in pregnant patients and patients who develop pancreatitis on therapy
• I slowly taper therapy over 9 to 12 weeks, along with coaching on a high protein/low carb diet and incorporation of resistance training exercises for patients who have reached their target weight
• For high-risk patients (e.g., those with T2DM, CVD, kidney disease, or PCOS), I discourage therapy discontinuation due to their associated long-term benefits
• Other