When are increased flank doses beneficial in Stage III Wilms tumor?
2 Answers
Mednet Member
Radiation Oncology · UC Health
The current standard of care in North America for radiotherapy dose in the treatment of Wilms tumor (WT) has been established by the National Wilms Tumor Study (NWTS)-3. This study randomized Stage III favorable histology patients to 1000 cGy vs. 2000 cGy as well as 2 drugs (actinomycin D and vincri...
Mednet Member
Radiation Oncology · UMass Memorial Medical Group
I believe this dose was determined by the AREN0321 protocol.
Typical indications for increased flank doses to 19.8 Gy in 11 fx include:
- Patients if ≥16 years of age
- Stage III tumors with diffuse anaplasia
- Stage I-III Rhabdoid tumor of the kidney if age > 1-year-old.
Note that a 10.8 Gy boost is added...