For patients with refractory Hidradenitis Suppurativa on biologic therapy, which specific agent, semaglutide, tirzepatide, or another GLP-1, has yielded the best clinical outcomes in your practice?
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Which adjunctive incretin-based therapy, if any, do you preferentially recommend for HS refractory to biologic therapy?
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2 Answers
Mednet MemberInvited Expert
Dermatology · Wayne State University
Answered on
I haven't seen enough patients on different medications to form an opinion. I have seen some tough HS cases where we were struggling to gain control improve notably after starting a GLP-1. I just haven't seen enough to draw comparisons yet.
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Mednet MemberInvited Expert
Dermatology · UCONN
Answered on
Given the challenges of getting GLP-1 RAs covered, anything is better than nothing, but tirzepatide has been the most consistent for me. I start at 2.5 mg SC weekly and then increase to 7.5 mg SC weekly over the first 3 months. I usually coast at 7.5 mg weekly for 2-3 months and then further increas...
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