When considering liver transplantation after downstaging beyond Milan criteria, what minimum downstaging endpoints (AFP response, radiographic response/necrosis, and required duration of stability) do you use to justify proceeding to transplant to optimize long-term overall survival?

I see several scenarios that will help with the answer.

Once successful downstaging is achieved and the patient has a living donor, they may proceed to transplant (if no checkpoint inhibitors for ideally 90 days or more than 30 days).

If no living donor is available, and the patient has a low MELD s...