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When considering the use of DOACs in APLS, does the number of positive APLS antibodies influence your decision?

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Would you consider a DOAC for single positive APLS?

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2 Answers
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Rheumatology · Hackensack University Medical Center
Answered on

The number of antibodies is an important consideration.

On the one end of the spectrum, I would not recommend any DOACs in a triple positive APLS (especially with arterial thrombosis). Having said that, I would not change treatment in a triple positive APLS patient if they were started on DOACs in th...

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Mednet Member
Mednet MemberInvited Expert
Rheumatology · UTMB Health
Answered on

I agree with Dr. @Dr. First Last's comments. The number of positive antibodies, their titers, and whether they are persistently positive versus intermittently positive all matter. Although warfarin is preferred in classic APS, I have seen patients with APS started on DOAC by hematologists, and they ...

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