When do you check neurofilament light chain in patients with neurodegenerative illnesses?

Neurofilament light chain polypeptide is a protein that can be released in blood or CSF during (active) injury to nerve axons in the CNS. Until recently, this was exclusively a research tool, and in the last 5-6 years we saw an explosion of publications, demonstrating the utility of this biomarker, for either monitoring the course of certain neurodegenerative and inflammatory CNS diseases (e.g. MS), or differentiating between certain neurodegenerative diseases and their mimics. Just to give a fe...