When do you consider certolizumab for pregnant women with antiphospholipid syndrome with positive lupus anticoagulant?
Do you consider it for all +LAC, APLS pregnant women? Or do you reserve it for women with recurrent late term losses, not responsive to hydroxychloroquine?
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What is your preferred first line therapy for pregnant women with APLS with placenta-mediated miscarriages?
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Hematology · Oregon Health & Science University
Answered on · Updated on
Certolizumab is a TNF-α antagonist with minimal or no transfer across the placenta. It was evaluated in the phase 2, open-label IMPACT (Improve Pregnancy in APS with Certolizumab Therapy) trial to prevent placenta-mediated adverse outcomes in pregnant patients with antiphospholipid antibody syndrome...
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