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When do you consider complement inhibitors or FcRN inhibitors in patients with myasthenia gravis?

These are new medications and, to my knowledge, there is no agreed-upon standardized approach as to when they should be used.
2 Answers
Mednet Member
Mednet MemberInvited Expert
Neurology · University of Minnesota
Answered on

In my opinion, those meds should be considered for a patient with AchR antibody-positive MG who has suboptimal control of MG symptoms on:

  1. Pyridostigmine + prednisone + oral immunosuppressant drugs like azathioprine or MMF.
  2. Pyridostigmine + oral immunosuppressant + severe intolerance to steroids (si...

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Mednet Member
Mednet MemberInvited Expert
Neurology · Cedars-Sinai Medical Center
Answered on

In theory, I agree with Dr. @Dr. First Last but for me, the answer is more complicated.

MMF and aza usually take many months to kick in, and it is not particularly useful to get the disease under control quickly. The concept that they should be used as "steroid-sparing agents" is good but one does a...

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