When do you discontinue PARP inhibitor maintenance after complete response to first line chemotherapy in a BRCA+ patient?
Is there a role for continuing beyond 24 months?
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When should PARPi maintenance be discontinued?
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2 Answers
Mednet Member
Medical Oncology · The Christie NHS Foundation Trust
Answered on · Updated on
I agree with Dr. @Dr. First Last that we have no data for PARPi maintenance beyond 2 years in the first line and would urge people to enroll in clinical trials which look at risks and benefits of longer maintenance, especially in patients harbouring a germline BRCA mutation.
With respect to all comers with platinum-sensitive recurrence, I would continue the PARPi until relapse, unacceptable toxicity, or patient preference. All of these women will eventually recur and I would balance benefits (PF...
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Mednet MemberInvited Expert
Gynecologic Oncology · University of Alabama at Birmingham
Answered on
Though it hasn't happened to me yet, the data would suggest no indication to continue PARPi beyond 2 years.
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