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When do you discontinue PARP inhibitor maintenance after complete response to first line chemotherapy in a BRCA+ patient?

2 Answers
Mednet Member
Mednet Member
Medical Oncology · Christie NHS Foundation Trust

I agree with Dr. @Dr. First Last that we have no data for PARPi maintenance beyond 2 years in the first line and would urge people to enroll in clinical trials which look at risks and benefits of longer maintenance, especially in patients harbouring a germline BRCA mutation.

With respect to all come...

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Mednet Member
Mednet Member
Gynecologic Oncology · University of Alabama at Birmingham

Though it hasn't happened to me yet, the data would suggest no indication to continue PARPi beyond 2 years.

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