When do you have a patient proceed to surgery for breast CA after completion of neoadjuvant chemotherapy if they developed a line-associated upper extremity DVT/VTE after completing chemo?

If it is port-associated thrombosis you can anti-coagulate using a short-acting anti-coagulant like therapeutic doses Lovenox (half-life 4.5 hrs.), and stop it 12-24 hours prior to surgery and re-start 5-6 days later depending on the surgeon's individual preference. If possible, I would wait 3-4 prior to surgery. The waiting periods prior to surgery and when to restart the Lovenox after surgery are empiric, but in the usual time frame of what is done in clinical practice.