When do you perform HER2 testing in patients with colorectal cancer?
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1 Answers
Mednet Member
Medical Oncology · University of Texas MD Anderson Cancer Center
HER2 amplification is seen in a small but distinct subset of colorectal cancer. This subset has 2 unique characteristics:
- They are predominantly RAS wild type tumors.
- They do not respond to anti-EGFR agents, i.e. HER2 amplification is a negative predictor of anti-EGFR antibody (cetuximab and panitu...