When do you stop trying to eradicate an acquired factor VIII inhibitor?

First, to be clear, the answer to this question is not well studied in any population, and the clinical setting (i.e. age, titer - historical max or current), and the nature of the complications isn't detailed here. I presume "no causative etiology" includes "not postpartum, and not accompanied by (...

Acquired factor VIII inhibitor causes a rare but life-threatening form of bleeding disorder. Treatment modalities have included the use of immunosuppressive drugs such as cyclophosphamide and corticosteroids, plasmapheresis, and I.V. immunoglobulin and rituximab.

I had two adult patients who could n...

I agree with Dr. @Dr. First Last that this is not well studied and that immunosuppressive therapy in an older patient is not always well tolerated. If the patient is not bleeding, then I would get rid of the more toxic immunosuppressive agents at least for a while.

However, if the inhibitor is stil...