When, if ever, do you recommend concurrent chemotherapy with definitive RT for early stage oral cavity squamous cell carcinoma?

Early stage oral cavity cancers are best treated with surgery or definitive RT including brachytherapy. If brachytherapy is not feasible and surgery is not an option, I would consider adding cisplatin but it would not be my first choice.

Surgery is the preferred treatment modality for early stage oral cavity cancers. For patients managed non-surgically, definitive RT with brachytherapy +/- external beam radiation therapy has a long track record in the management of early stage oral cavity cancers. Both ABS and GEC-ESTRO brachytherap...