When (if ever) would you offer radiotherapy for renal cell carcinoma following nephrectomy?

There is no indication for any type of radiation after nephrectomy in resected RCC. Often a 'positive' renal vein margin is not a true positive, but rather an artifact of having a renal vein thrombus and this should be discuss with the Urologist and Pathologist and clarified in the report. Having sa...

I have not personally offered radiation in this setting.

A PS-weighted multi-institutional study (excluding patients with neoadjuvant therapy or non-vascular margin positivity) found that positive vascular margins are associated with an increased risk of local recurrence with no difference in distant...

Agree that there is really no modern data with modern surgical techniques and high-quality post-operative imaging to justify routine post-op RT.

However, to say there is no data on the post-operative benefit of RT for RCC is an overstatement. Tunio et al. published in Annals of Oncology in 2010 a met...