When is the ideal time in the disease course to offer radiotherapy for Dupuytren's disease for the most optimal outcomes?

Radiotherapy is most effective when fibroblasts are actively proliferating, i.e., during the cellular or proliferative phase of the disease, when there is a palpable, progressive nodule or cord but no fixed contracture.
Prospective German trials show that treating during this biologically active peri...

This is one of the key questions we are trying to clarify in the DEPART trial. Patients were eligible to be randomized between radiotherapy and observation if <10 degree contracture of a joint, and some evidence of progression over the last 12 months. Final results are expected in 2027.

Given that ra...