When should adjuvant chemotherapy be offered to patients with soft tissue sarcoma of the extremity?

With conflicting data from the EORTC RCT and the Sarcoma meta-analysis collaboration, what factors determine when you would offer adjuvant chemotherapy to patients with soft tissue sarcoma of the extremity? https://www.ncbi.nlm.nih.gov/pubmed/9400508 https://www.ncbi.nlm.nih.gov/pubmed/22954508 How do you sequence chemotherapy and radiation?

Community PollStarted

When do you add chemotherapy as adjuvant care of localized extremity sarcomas?

11 physicians have voted

Join Mednetto vote and see how they answered.

2 Answers

Mednet MemberInvited Expert

Medical Oncology · University of Texas MD Anderson Cancer Center

Answered on

The disclaimer is, this continues to be an area of debate and discussion. Having said that, the best I can do in this forum/format:

Good PS, normal organ function, high-risk STS (stage 3), extremity/superficial trunk location, excluding low/non-responsive histologies (e.g. CSS, ASPS, SFT...) should ...

Join for free or sign in to see the full answer

Mednet Member

Medical Oncology · Dana-Farber Cancer Institute

Answered on

This is a complex question without a singular answer.

I would suggest taking a look at the more recent neoadjuvant publications including the one below

Pasquali et al., PMID 34643947.

Join for free or sign in to see the full answer