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Neurology • Neuro-immunology
When should MOG-Ab be tested in patients with suspected autoimmune encephalitis with seizures and normal MRI?
In light of how MOG-Ab is excluded on panels like Mayo ENS2.
Answer from: at Academic Institution
In someone with suspected autoimmune encephalitis with seizures and a normal MRI (presuming done with gadolinium and the optic nerves are well visualized), I would not obtain MOG. MOG testing would have a very low pretest probability (so low that a positive test might well be a false positive). If o...
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Answer from: at Academic Institution
In my opinion, it should be tested. MOGAD phenotype is expanding. I have recently seen a MOG Ab+ case presenting with encephalitis, seizure, and a normal MRI, abnormal PET brain.