When testing for patients with symptoms of MPN, do you prefer to do JAK2 cascade testing or a leukemia NGS testing panel?

Oftentimes, the symptoms related to MPNs are quite non-specific (fatigue, anorexia), so I typically look for other pieces of information from the CBC with differential and physical exam (e.g., splenomegaly). If the clinical suspicion for an MPN is high and I am pursuing confirmatory testing with a b...

Genetic testing with regard to the MPN can be usefully employed both diagnostically and prognostically. With respect to diagnosis, if an MPN is suspected based on symptoms such as aquagenic pruritis, ocular migraine, erythromelalgia, or the occurrence of an unexplained thrombosis, the first laborato...