When treating an inoperable patient with squamous cell carcinoma of the thoracic esophagus, do you ever dose escalate beyond 50.4Gy?

Given the results of INT-0123/RTOG9405 failed to demonstrate an improvement in overall survival with dose escalation, I do not treat above 50.4 Gy when giving definitive chemoradiation. There is no other randomized evidence to support doses greater than 50-50.4 Gy at 1.8-2.0 Gy/day.

Patients treated in the INT-0123 trial mainly received 2-dimensional techniques, and so we examined data from the NCDB from 2004-2012 with over 6,000 patients and did not find an overall survival benefit with dose esc...