When treating bladder cancer with CRT in the bladder preservation paradigm, do you cone down to partial bladder or the whole bladder?

I agree with @Dr. First Last about whole vs. partial bladder "cone-down", although in my experience I'm much less like than @Dr. First Last to treat partial bladder. In addition to the trials mentioned, the old SWOG experience (Combined 5-fluorouracil and irradiation for transitional cell carcinoma ...

I treat partial bladder when I can, maybe 2/3 of the time, and whole bladder when I can't, about 1/3 of the time. I have done this with platinum and 5-FU for many years and more recently with 5FU and MMC. Whole bladder seems equally tolerated for both chemo regimens but that is an unscientific compa...

It is hard to say if cisplatinum would be more toxic than 5fu and mmc as there is no comparative study. Both have shown good tolerance independently with acceptable morbidities. One important caveat is dose of 5fu used in the study was half of what us used for anal cancer (500 vs 1000mg/m2) and coul...