When treating DLBCL with induction therapy with R-CHOP, if after 2 cycles, you have a mixed response on PET, would you consider that treatment failure or would you continue R-CHOP?

Topics: Hematologic Malignancies • Medical Oncology • Lymphoma • Hematology

Answer from: Medical Oncologist at Academic Institution

First, it is not routine practice to evaluate response to RCHOP radiographically after 2 cycles of treatment for DLBCL. If there were clinical concern that the patient were not responding, and imaging was performed with a mixed response - both frankly progressive disease and responding d...

Comments

Medical Oncologist at Florida Cancer Specialists
NCCN below Interim restaging after 2–...

Medical Oncologist at Stamford Hospital
Hi, in this case the patient had a CT scan after C...

Medical Oncologist at Rutgers Cancer Institute of New Jersey
@Mark S. Rubin: I prefer interim restaging at 4 cy...

Answer from: Medical Oncologist at Academic Institution

The prognostic implication of iPET in DLBCL (as oppose of Hodgkin's lymphoma) has been controversial. The PETAL study (PET scan was performed after 2 and 4 cycles) is perhaps the largest study looking at the value of iPET in DLBCL, using delta SUV as oppose of standard Deauville criteria. Unfortunat...

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