When treating DLBCL with induction therapy with R-CHOP, if after 2 cycles, you have a mixed response on PET, would you consider that treatment failure or would you continue R-CHOP?

First, it is not routine practice to evaluate response to RCHOP radiographically after 2 cycles of treatment for DLBCL. If there were clinical concern that the patient were not responding, and imaging was performed with a mixed response - both frankly progressive disease and responding disease - the...

The prognostic implication of iPET in DLBCL (as oppose of Hodgkin's lymphoma) has been controversial. The PETAL study (PET scan was performed after 2 and 4 cycles) is perhaps the largest study looking at the value of iPET in DLBCL, using delta SUV as oppose of standard Deauville criteria. Unfortunat...