When treating with SBRT and immunotherapy for unresectable HCC, how do you sequence the treatment?
Data are scattered, with some starting concurrent and some starting after SBRT to optimize the priming of the immune system with RT.
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Massachusetts General Hospital
Answered on
Great question. No great data in this space regarding optimal sequencing. In general, I would sequence SBRT first, followed by initiation of immunotherapy. Some data suggest that SBRT may best prime IO if administered prior to IO.
Additionally, if the IO regimen preferred is atezolizumab/bevacizumab...
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