When would you consider testing for LGI1 antibodies in patients with unexplained neuropathic pain?

I would strongly consider testing CASPR2 and LGI1 antibodies in any patient with unexplained, subacute or chronic "neuropathic-sounding" pain (e.g. described as hot/burning, stabbing, "pins-needles", etc) especially if: exacerbated by heat, experienced diffusely in a "non-length dependent" pattern (...

I would consider LGI1 antibody testing when unexplained neuropathic pain occurs in the context of a broader clinical presentation suggestive of neuronal autoimmunity, particularly when symptoms exhibit a subacute progression or are accompanied by subtle central neurological manifestations.

From a pa...