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When would you consider testing for LGI1 antibodies in patients with unexplained neuropathic pain?

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Mednet Member
Mednet Member
Neurology · University of Minnesota

I would strongly consider testing CASPR2 and LGI1 antibodies in any patient with unexplained, subacute or chronic "neuropathic-sounding" pain (e.g. described as hot/burning, stabbing, "pins-needles", etc) especially if: exacerbated by heat, experienced diffusely in a "non-length dependent" pattern (...

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