When you do recommend conventional fractionation over moderate hypofractionation for prostate cancer?

I am routinely using 2.5-3 Gy in patients with low, intermediate, and some high risk patients so I guess I am an early adopter (or a cavalier nutjob). The exclusion criteria from the two published non-inferiority trials of moderate hypofractionation that are relevant to this question are quoted more...

At Fox Chase, the overwhelming majority of our prostate patients who are treated with IMRT are treated with some form of hypofractionation (moderate hypofx or SbRT). Based on our own phase III randomized prospective trial (long-term results were published in 2020 - Avkshtol et al. PMID 32119599) as ...

I concur with @Dr. First Last's response. We will wait for the RTOG 0415. At the Scripps proton therapy center, we have been treating most of our prostate patients using the 70 Gy in 28 fractions with simulteous boost to the DIL (seen on MRI) to 78 Gy using Intensity Modulated Proton Therapy. The on...

I had measured some unexpectedly fortuitous and significant lowering of the IPSS in IPSS>20 patients undergoing 81 Gy/45 fx IG-IMRT (the "old" popular MSKCC regimen). In my experience, 79 of 81 IPSS>20 patients had a stable or (much) lower IPSS after 1.8 Gy daily fractional doses. ( @Dr. First Last....