Which BRAF/MEK inhibitor combination have you found most tolerable and easiest to prescribe in good performance patients with mutated metastatic melanoma?

I prefer using encorafenib and binimetinib. Although the number of pills is many (almost 12 a day), the most common toxicity I have encountered is GI toxicity of nausea and vomiting followed by occasional diarrhea. One patient, in my entire experience of six years of treating melanoma, reported feve...

I think it’s helpful to know the peculiar side effects of each targeted therapy drug and their clinical data for particular clinical situations. Dabrefenib/trametinib has CNS efficacy data. It’s my treatment of choice for patients with CNS metastases. Although pyrexia is a common side effect, it can...