Which factors help you choose between intermittent phenobarbital dosing versus continuous pentobarbital infusion for pharmacological burst suppression in refractory status epilepticus?

I am not aware of any guidelines or data that recommend the use of phenobarbital over pentobarbital for burst suppression in refractory status epilepticus. In fact, guidelines tend to favor pentobarbital in patients who have failed propofol and midazolam. Phenobarbital can certainly be used for seiz...

I do not use intermittent phenobarbital for pharmacological burst suppression. If burst suppression is the treatment target, pentobarbital is the treatment of choice, given its ease of administration and shorter duration of action.