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Which serologic tests are most helpful when evaluating for suspected drug-induced lupus?

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Mednet Member
Mednet Member
Dermatology · Stanford University School of Medicine

If I suspect drug-induced lupus, I typically order the following laboratory testing:

  • ANA/IFA
  • Anti-histone antibody, usually positive in drug-induced lupus
  • Anti-Ro antibody, usually positive in drug-induced subacute cutaneous lupus
  • Anti-dsDNA, usually negative in drug-induced lupus vs positive in id...

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Mednet Member
Mednet Member
Rheumatology · Uniformed Services University of the Health Sciences (USUHS)

Agree with @Jennifer Yeh and the nuances noted by @Steven Feldman are incredibly important. Histone ab is so common in SLE, that you really need to have a high pretest probability, e.g., lupus sxs appearing after starting drugs like hydralazine, procainamide, or isoniazid.

These days, I'm more apt to...

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