Which serologic tests are most helpful when evaluating for suspected drug-induced lupus?

If I suspect drug-induced lupus, I typically order the following laboratory testing:

• ANA/IFA
• Anti-histone antibody, usually positive in drug-induced lupus
• Anti-Ro antibody, usually positive in drug-induced subacute cutaneous lupus
• Anti-dsDNA, usually negative in drug-induced lupus vs positive in id...

Agree with @Dr. First Last and the nuances noted by @Dr. First Last are incredibly important. Histone ab is so common in SLE, that you really need to have a high pretest probability, e.g., lupus sxs appearing after starting drugs like hydralazine, procainamide, or isoniazid.

These days, I'm more apt ...