Which systemic therapy would you use to treat a poorly-differentiated round cell sarcoma with CIC-DUX4 gene fusion?

CIC-DUX4 fusion sarcoma is a rare entity, the aggressiveness of which is comparable to Ewing's sarcoma. A major dilemma is whether to treat these patients with Ewing's like regimen (VDC/IE) or generic sarcoma regimen (AIM).

Answer from: Medical Oncologist at Academic Institution

A patient with a sarcoma such as this should be evaluated at a multidisciplinary sarcoma center, including pathology review. I would favor treating with a Ewing sarcoma regimen as these can be very aggressive tumors. A small series recently reported at the annual CTOS meeting of CIC rearranged small...

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Medical Oncologist at Agnesian Cancer Center
Thank you Dr Wagner for your response. Since this ...

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