Which targeted systemic agents should be held while delivering palliative radiation?

Great question regarding the use of systemic therapy for cancer during palliative radiation. First, regarding targeted therapies, there are no reports of targeted therapies which would be unsafe or should be held during palliative radiotherapy. Most targeted agents are monoclonal antibodies to recep...

I'm not sure if this case was published, but I am aware of a case of Gr3-4 dermatitis after a few fractions of palliative RT in a patient taking Vemurafanib. This was shortly after FDA approval of the drug.

It seemed like a clear case of radiosensitizing.

Here is a good review article on BRAF inhibitor and enhanced RT toxicity.