Would a high Decipher score affect your recommendation regarding the addition of ADT to XRT in a favorable intermediate risk prostate patient?

The simple answer is YES.

To walk through why...

1. Trials like RTOG 9408 demonstrate that there is a metastasis and OS benefit in Intermediate Risk disease from the addition of short-term ADT to RT.

2. Later work from many groups showed that intermediate risk is a very heterogeneous cohort. This shoul...

Would appreciate some follow-up on favorable intermediate risk with high Decipher.

For instance, a man in his 70s with PSA 4.3 with 2/12 cores G6 a year ago. Follow-up surveillance template 12 core biopsy shows 2 cores G7 (3+4), low volume, and PSA 4.08. Johns Hopkins review of path confirmatory, MR...