Would a history of definitive chemoRT for anal SCC change the workup for an ASCUS/HPV negative PAP smear in a patient who has never had an abnormal PAP smear in the past?

Interesting question. We do know that radiation changes can lead to atypia which can interfere with cytological analysis. I would counsel the patient that her current ASCUS/HPV negative pap smear results may have some relation to her prior radiation, but ultimately I would still follow ASCCP guideli...