Would OncotypeDx impact your decision to provide adjuvant chemotherapy for node-negative HR+ breast cancer with dermis or chest wall involvement?

Topics: Breast Cancer • Medical Oncology • Breast Cancer, Non-metastatic

Would you recommend adjuvant chemotherapy for pT4 disease regardless of Oncotype score?

Answer from: Medical Oncologist at Academic Institution

While I'm tempted to use Oncotype or other genomic assays to omit chemotherapy as much as possible (and TBH, Oncotype may be more of a prognostic than predictive assay except at the very upper range - see Mitch Dowsett's examination of these assays, Buus et al., PMID 33108242), the prospective trial...

Comments

Medical Oncologist at Wenatchee Valley Med Center
I would be more tempted to omit if it were lobular...

Medical Oncologist at Overlook Medical Center
In general, I would agree. In a related group, i.e...

Medical Oncologist at Mary Lanning Healthcare Morrison Cancer Center
Invasion to dermis alone is not qualified as T4? I...

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