Would the presence of multifocal LVSI change your adjuvant treatment recommendation for a surgically staged IA dedifferentiated endometrial carcinoma?

Dedifferentiated is considered a high-grade lesion. There is admittedly low quality evidence on optimal management given lower incidence.

I would recommend treatment with vaginal brachytherapy and very much offer chemotherapy. Would prefer vaginal brachytherapy, given the patient was surgically stage...

While a dedifferentiated Endometrial Cancer is a high grade lesion, in my opinion, it is not to be bundled in with high grade, Grade 3 endometrioid malignancies. A recent review by Goh et al., PMID 32090165, renewed their experience with 7 dedifferentiated malignancies. In this center, their OS for ...