Would uterine serosal involvement change your adjuvant treatment recommendation for a patient with Stage II grade 2 endometrial cancer?

Would recommend chemotherapy and vaginal brachytherapy.

Had the patient had Stage II, Grade 2 disease (ignore the ITC for a moment), we would offer the patient pelvic radiation therapy alone based on GOG 249 and PORTEC 3 results, the latter of which showed a benefit of chemotherapy largely driven by...

Serosal involvement in endometrial cancer upstages a patient to Stage IIIA. Despite a likely risk of recurrence in the pelvis/vagina for a cancer that involves the cervix, the standard of care for this stage is chemotherapy. Some, however, might include radiation therapy either in a sandwiched appro...